resveratrol and red wine function as antioxidants in the nervous system without cellular proliferative effects during experimental diabetes白藜芦醇和红酒作为抗氧化剂在神经系统细胞的增殖效应在实验性糖尿病.pdfVIP

Resea RCh papeR Oxidative Medicine and Cellular Longevity 3:6, 434-441; November/December 2010; © 2010 Landes Bioscience Resveratrol and red wine function as antioxidants in the central nervous system without cellular proliferative effects during experimental diabetes 1,3 2 4 2 1,5, Carina Duarte Venturini, suélen Merlo, andré arigony souto, Marilda da Cruz Fernandes, Rosane Gomez * and Claudia 1 Ramos Rhoden 1Universidade Federal de Ciências da saúde de porto alegre (UFCspa); Division of pharmacology; and 2 Division of histology; 3 pontifícia Universidade Católica do Rio Grande do sul (pUCRs); Institute of Geriatrics and Gerontology and 4 Department of Chemistry; 5 Universidade Federal do Rio Grande do sul (UFRGs); Department of pharmacology; porto alegre, Brazil Key words: grape, diabetic encephalopathy, supplements, polyphenols, hippocampus, striatum, frontal cortex Chronic hyperglycemia increases oxidative stress status and has been associated with neurological complications in diabetic individuals. This study compared the antioxidant properties of red wine or resveratrol in different brain areas of diabetic and non-diabetic rats, and investigated the effect of them on hippocampal cell proliferation in hippocampal dentate gyrus of diabetic rats. streptozotocin-induced diabetic and control rats were treated with red wine (4 mL/ kg), resveratrol (20 mg/kg) or saline, by oral gavage, for 21