resveratrol produces neurotrophic effects on cultured dopaminergic neurons through prompting astroglial bdnf and gdnf release白藜芦醇产生神经营养对培养的影响通过促使astroglial bdnf和多巴胺神经元gdnf释放.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 937605, 7 pages doi:10.1155/2012/937605 Research Article Resveratrol Produces Neurotrophic Effects on Cultured Dopaminergic Neurons through Prompting Astroglial BDNF and GDNF Release Feng Zhang,1 Yan-Ying Wang,1 Hang Liu,2 Yuan-Fu Lu,1 Qin Wu,1 Jie Liu,3 and Jing-Shan Shi1 1 Department of Pharmacology and Key Lab of Basic Pharmacology of Guizhou, Zunyi Medical College, Zunyi 563099, China 2 Pharmacy School, Zunyi Meidcal College, Zunyi 563099, China 3 University of Kansas Medical Center, Kansas City, KS 66160, USA Correspondence should be addressed to Feng Zhang, zhangfengzmc@163.com Received 12 September 2012; Revised 29 October 2012; Accepted 30 October 2012 Academic Editor: Olumayokun A. Olajide Copyright © 2012 Feng Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Increasing evidence indicated astroglia-derived neurotrophic factors generation might hold a promising therapy for Parkinson’s disease (PD). Resveratrol, naturally present in red wine and grapes with potential benefit for health, is well known to possess a number of pharmacological activities. Besides the antineuroinflammatory properties, we hypothesized the neuroprotective potency of resveratrol is partially due to its additional neurotrophic effects. Here, primary rat midbrain neuron-glia cultures were applied to investigate the neurotrophic effects mediated by resveratrol on dopamine (DA) neurons and further explore the role of neurotrophic factors in its actions. Results showed resveratrol produced neurotrophic effects on cu