noise reduction and image quality improvement of low dose and ultra low dose brain perfusion ct by hypr-lr processing减少噪声和图像质量改善低剂量和超低剂量脑灌注ct hypr-lr处理.pdfVIP

Noise Reduction and Image Quality Improvement of Low Dose and Ultra Low Dose Brain Perfusion CT by HYPR-LR Processing 1 2 1 3 Radko Krissak *, Charles A. Mistretta , Thomas Henzler , Anastasios Chatzikonstantinou , Johann 4 1 1 Scharf , Stefan O. Schoenberg , Christian Fink 1 Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany, 2 Department of Medical Physics, University of Wisconsin, Madison, Wisconsin, United States of America, 3 Department of Neurology, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany, 4 Department of Neuroradiology, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany Abstract Purpose: To evaluate image quality and signal characteristics of brain perfusion CT (BPCT) obtained by low-dose (LD) and ultra-low-dose (ULD) protocols with and without post-processing by highly constrained back-projection (HYPR)–local reconstruction (LR) technique. Methods and Materials: Simultaneous BPCTs were acquired in 8 patients on a dual-source-CT by applying LD (80 kV,200 mAs,14 61.2 mm) on tube A and ULD (80 kV,30 mAs,1461.2 mm) on tube B. Image data from both tubes was reconstructed with identical parameters and post-processed using the HYPR-LR. Correlation coefficients between mean and maximum (MAX) attenuation values within corresponding ROIs, area under attenuation curve (AUC), and signal to noise ratio (SNR) of brain parenchyma were assessed. Subjective image q