selective vulnerability of neurons in layer ii of the entorhinal cortex during aging and alzheimers disease选择性的脆弱性在层二世内嗅皮层神经元衰老和老年痴呆症.pdfVIP

Hindawi Publishing Corporation Neural Plasticity Volume 2010, Article ID 108190, 8 pages doi:10.1155/2010/108190 Review Article Selective Vulnerability of Neurons in Layer II of the Entorhinal Cortex during Aging and Alzheimer’s Disease Alexis M. Stranahan1 and Mark P. Mattson2 1 Department of Psychological and Brain Sciences, Johns Hopkins University, Ames Hall, 3400 N. Charles St., Baltimore, MD 21218, USA 2 Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA Correspondence should be addressed to Alexis M. Stranahan, alexis.stranahan@ Received 24 August 2010; Accepted 26 October 2010 Academic Editor: M. B. Dutia Copyright © 2010 A. M. Stranahan and M. P. Mattson. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. All neurons are not created equal. Certain cell populations in specific brain regions are more susceptible to age-related changes that initiate regional and system-level dysfunction. In this respect, neurons in layer II of the entorhinal cortex are selectively vulnerable in aging and Alzheimer’s disease (AD). This paper will cover several hypotheses that attempt to account for age- related alterations among this cell population. We consider whether specific developmental, anatomical, or biochemical features of neurons in layer II of the entorhinal cortex contribute to their particular sensitivity to aging and AD. The entorhinal cortex is a functionally heterogeneous environment, and we will also review data suggesting that, within the entorhinal cortex, there is subregion