stability on coupling sir epidemic model with vaccination稳定耦合爵士流行模型与接种疫苗.pdfVIP

STABILITY ON COUPLING SIR EPIDEMIC MODEL WITH VACCINATION HELONG LIU, HOUBAO XU, JINGYUAN YU, AND GUANGTIAN ZHU Received 9 December 2004 and in revised form 21 September 2005 We develop a mathematical model for the disease which can be transmitted via vector and through blood transfusion in host population. The host population is structured by the chronological age. We assume that the instantaneous death and infection rates depend on the age. Applying semigroup theory and so forth, we investigate the existence of equilibria. We also discuss local stability of steady states. 1. Introduction Age-structured epidemic models have been investigated by many authors [5, 6, 9, 11, 15]. We may find that the epidemic models that most authors discussed mainly include SIS, SIR, and SEIR, that is, the total population of a country or a district was divided into two, three, or four compartments containing susceptibles, exposed, infective, and removed individuals. They have got the threshold conditions for the disease to become endemic, and described the stability of steady-state solutions. However, they did not consider the effects of vector in disease transmission. In fact, many diseases such as malaria, Chagas disease, dengue fever, are transmitted via vector. Therefore, it is necessary and also it is of practical significance to consider the dynamics that includes host population and vector population. So far some authors have studied the mathematical models [2, 3, 7]. Feng et al. in [2] assumed that the population dynamics of malaria and the population genetics of the sickle-cell genes occur on different time scales, formulated vector-host model for malaria, and used the system of ordinary differential equations to describe the model. Inaba and Sekine [7] discussed a vector-host model for the spread of Chagas disease with infection-age. In this article, we formulate a vector-host model for the disease which is transmit- ted via vector and through blo