shift work, jet lag, and female reproduction轮班工作,时差和女性生殖.pdfVIP

Hindawi Publishing Corporation International Journal of Endocrinology Volume 2010, Article ID 813764, 9 pages doi:10.1155/2010/813764 Review Article Shift Work, Jet Lag, and Female Reproduction Megan M. Mahoney Veterinary Biosciences and Neuroscience Program, University of Illinois, 3639 VMBSB MC-002, 2001 S Lincoln Avenue, Urbana, IL 61802, USA Correspondence should be addressed to Megan M. Mahoney, mmm1@ Received 22 October 2009; Accepted 2 January 2010 Academic Editor: Jessica A. Mong Copyright © 2010 Megan M. Mahoney. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Circadian rhythms and “clock gene” expression are involved in successful reproductive cycles, mating, and pregnancy. Alterations or disruptions of biological rhythms, as commonly occurs in shift work, jet lag, sleep deprivation, or clock gene knock out models, are linked to significant disruptions in reproductive function. These impairments include altered hormonal secretion patterns, reduced conception rates, increased miscarriage rates and an increased risk of breast cancer. Female health may be particularly susceptible to the impact of desynchronizing work schedules as perturbed hormonal rhythms can further influence the expression patterns of clock genes. Estrogen modifies clock gene expression in the uterus, ovaries, and suprachiasmatic nucleus, the site of the primary circadian clock mechanism. Further work investigating clock genes, light exposure, ovarian hormones, and reproductive function will be critical for indentifying how these factors interact to impact health and susceptibility to disease. 1. Introduction