statins for renal patients a fiddler on the roof他汀类药物对肾患者屋顶上的提琴手.pdfVIP

Hindawi Publishing Corporation International Journal of Nephrology Volume 2012, Article ID 806872, 7 pages doi:10.1155/2012/806872 Review Article Statins for Renal Patients: A Fiddler on the Roof? ˜ Anabela Malho Guedes and Pedro Leao Neves Servic¸o de Nefrologia, Hospital de Faro, 8000 Faro, Portugal Correspondence should be addressed to Anabela Malho Guedes, anabelamalho@ Received 17 July 2012; Revised 22 September 2012; Accepted 24 September 2012 Academic Editor: Alessandro Amore Copyright © 2012 A. M. Guedes and P. L. Neves. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Atherosclerotic cardiovascular disease is the main cause of morbidity and mortality in chronic kidney disease patients. There is a raft of evidence showing that in the general population dyslipidaemia is associated with an increased risk of cardiovascular events, as well as with a greater prevalence of chronic kidney disease. Consequently, the use of statins in the general population with dys- lipidaemia is not controversial. Nevertheless, the benefits of statins in patients with chronic kidney disease are more elusive. The authors review the possible effects of statins on the progression of renal disease and cardiovascular events in chronic kidney disease patients. 1. Introduction for both renal disease progression and dyslipidaemia [7]. Evi- dence suggests that in the early stages of renal impairment, Atherosclerotic cardiovascular di