should histologic grade be incorporated into the tnm classification system for small (t1, t2) node-negative breast adenocarcinomas组织学分级应纳入tnm分类系统对小(t1,t2)乳腺腺癌.pdfVIP

SAGE-Hindawi Access to Research Pathology Research International Volume 2011, Article ID 825627, 4 pages doi:10.4061/2011/825627 Research Article Should Histologic Grade Be Incorporated into the TNM Classification System for Small (T1, T2) Node-Negative Breast Adenocarcinomas? Mathew Purdom,1 Michael L. Cibull,1 Terry D. Stratton,2 Luis M. Samayoa,1 Edward H. Romond,3 Patrick C. Mcgrath,3 and Rouzan G. Karabakhtsian1 1 Department of Pathology Laboratory Medicine, Chandler Medical Center, College of Medicine, University of Kentucky, 800 Rose Street, MS 129, Lexington, KY 40536, USA 2 Department of Behavioral Sciences, University of Kentucky, Lexington, KY 40506, USA 3 Comprehensive Breast Care Center, Markey Cancer Center, Lexington, KY 40536, USA Correspondence should be addressed to Rouzan G. Karabakhtsian, rkara2@ Received 14 September 2010; Accepted 8 October 2010 Academic Editor: Rohit Bhargava Copyright © 2011 Mathew Purdom et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Prognosis of invasive ductal carcinoma (IDC) strongly correlates with tumor grade as determined by Nottingham combined histologic grade. While reporting grade as low grade/favorable (G1), intermediate grade/moderately favorable (G2), and high grade/unfavorable (G3) is recommended by American Joint Committee on Cancer (AJCC) staging system, existing TNM (Primary Tumor/Regional Lymph Nodes/Distant Metastasis) classification does not directly incorporate these data. For large tumors (T3, T4), significance of histologic grade may be clinically moot as those are nearly always candidates for adjuvant therapy