suppression of peroxisomal enzyme activities and cytochrome p450 4a isozyme expression by congeneric polybrominated and polychlorinated biphenyls抑制酶的酶活性和细胞色素p450 4的同工酶表达同类的多溴化和多氯联苯.pdfVIP

Hindawi Publishing Corporation PPAR Research Volume 2007, Article ID 15481, 5 pages doi:10.1155/2007/15481 Research Article Suppression of Peroxisomal Enzyme Activities and Cytochrome P450 4A Isozyme Expression by Congeneric Polybrominated and Polychlorinated Biphenyls Larry W. Robertson,1, 2 Isabelle Berberian,1 Tim Borges,1, 3 Li-Chuan Chen,1 Ching K. Chow,1, 4 Howard P. Glauert,1, 4 Johannes G. Filser,5 and Helmut Thomas6 1 Graduate Center for Toxicology, University of Kentucky, Funkhouser Building, Lexington, KY 40506-0054, USA 2 Department of Occupational and Environmental Health, College of Public Health, University of Iowa, 124 IREH 100 Oakdale Campus, Iowa City, IA 52242-5000, USA 3 Oak Ridge National Laboratory, Oak Ridge, TN 37830, USA 4 Graduate Center for Nutritional Sciences, University of Kentucky, Funkhouser Building, Lexington, KY 40506-0054, USA 5 GSF-National Research Center For Environment and Health, Institute of Toxicology, Ingolstadter Landstraße 1, ¨ 85716 Neuherberg, Germany 6 Tranzyme Pharma Inc., 3001 12th Avenue North, Building Z5-3037, Sherbrooke, QC, Canada J1H 5N4 Correspondence should be addressed to Larry W. Robertson, larry-robertson@ Received 30 May 2007; Accepted 10 August 2007 Recommended by Jihan Youssef The purpose of this study was to determine the effects of PCBs and PBBs on peroxisome proliferator-activated receptor- α-(PPARα-) associated enzyme activities or protein levels. Male Sprague-Dawley rats were administered a single IP injec- tion (150 μmol/kg) of either 3,3’,4,4’-tetrabromobiphenyl, 3,3’,4,4’-tetrachlorobiphenyl, 3,3’,5,5’-tetrabromobiphenyl, 2’,3,3’,4,5- pentachlorob