surface engineered polymeric biomaterials with improved biocontact properties表面工程高分子生物材料与改善biocontact属性.pdfVIP

Hindawi Publishing Corporation International Journal of Polymer Science Volume 2010, Article ID 296094, 22 pages doi:10.1155/2010/296094 Review Article Surface Engineered Polymeric Biomaterials with Improved Biocontact Properties Todorka G. Vladkova Laboratory for Advanced Materials, Department of Polymer Engineering, University of Chemical Technology and Metallurgy, 8 Kl. Ohridski Boulevard., 1756 Sofia, Bulgaria Correspondence should be addressed to Todorka G. Vladkova, tgv@ Received 4 August 2009; Revised 24 November 2009; Accepted 31 March 2010 Academic Editor: Shanfeng Wang Copyright © 2010 Todorka G. Vladkova. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We present many examples of surface engineered polymeric biomaterials with nanosize modified layers, controlled protein adsorption, and cellular interactions potentially applicable for tissue and/or blood contacting devices, scaffolds for cell culture and tissue engineering, biosensors, biological microchips as well as approaches to their preparation. 1. Introduction often a polymeric biomaterial that should stimulate not only the cell attachment and differentiation but also the extra On many parameters, polymeric materials satisfy the cellular matrix formation and tissue regeneration. Advanced requirements of biomedical applications. However, the last biospecific and biomimetic materials consisting of bioinert ones are limited in most cases by the nonsufficient biocon-