survival benefit of adjuvant radiation therapy for gastric cancer following gastrectomy and extended lymphadenectomy生存利益的辅助放射治疗胃癌胃切除术后和扩展淋巴切除术.pdfVIP

Hindawi Publishing Corporation International Journal of Surgical Oncology Volume 2012, Article ID 307670, 7 pages doi:10.1155/2012/307670 Research Article Survival Benefit of Adjuvant Radiation Therapy for Gastric Cancer following Gastrectomy and Extended Lymphadenectomy R. A. Snyder,1 E. T. Castaldo,1 C. E. Bailey,1 S. E. Phillips,2 A. B. Chakravarthy,3, 4 and N. B. Merchant1, 4, 5 1 Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA 2 Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA 3 Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA 4 Vanderbilt Ingram Cancer Center, Nashville, TN 37232-6860, USA 5 Division of Surgical Oncology, Vanderbilt University Medical Center, 597 Preston Research Building, Nashville, TN 37232, USA Correspondence should be addressed to N. B. Merchant, nipun.merchant@ Received 30 January 2012; Accepted 6 May 2012 Academic Editor: Lapo Bencini Copyright © 2012 R. A. Snyder et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Purpose. Although randomized trials suggest a survival benefit of adjuvant chemotherapy and radiation therapy (XRT) for gastric adenocarcinoma, its use in patients who undergo an extended lymphadenectomy is less clear. The purpose of this study was to determine if a survival benefit exists in gastric cancer patients who receive adjuvant XRT following resection with extended lymphadenectomy. Methods. The SEER registry was queried for records of patients with resected gastric adenocarcinoma from 1988 to 2007. Multivar