spatial organization and dynamics of transcription elongation and pre-mrna processing in live cells空间组织和动态转录在活细胞伸长和pre-mrna处理.pdfVIP

SAGE-Hindawi Access to Research Genetics Research International Volume 2011, Article ID 626081, 10 pages doi:10.4061/2011/626081 Review Article Spatial Organization and Dynamics of Transcription Elongation and Pre-mRNA Processing in Live Cells 1 2 2 ´ ´ ´ ´ ´ ˜ ´ Miguel Sanchez-Alvarez, Noemı Sanchez-Hernandez, and Carlos Sune 1 Dynamical Cell Systems Team, Section of Cellular and Molecular Biology, The Institute of Cancer Research, London SW3 6JB, UK 2 Department of Molecular Biology, Instituto de Parasitologıa y Biomedicina “Lopez Neyra” (IPBLN-CSIC), 18100 Armilla, Spain ´ ´ ˜ ´ Correspondence should be addressed to Carlos Sune, csune@ipb.csic.es Received 22 July 2011; Accepted 5 September 2011 ´ ´ Academic Editor: Sebastian Chavez ´ ´ Copyright © 2011 Miguel Sanchez-Alvarez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. During the last 30 years, systematic biochemical and functional studies have significantly expanded our knowledge of the transcriptional molecular components and the pre-mRNA proc