sustained delivery of nicotinamide limits cortical injury and improves functional recovery following traumatic brain injury持续交付的烟酰胺限制皮质损伤和改善创伤性脑损伤后功能恢复.pdfVIP

ReseARCh pA peR ReseARCh pApeR Oxidative Medicine and Cellular Longevity 3:2, 145-152; March/April 2010; © 2010 Landes Bioscience Sustained delivery of nicotinamide limits cortical injury and improves functional recovery following traumatic brain injury 1 2 1, Andrea M. Goffus, Gail D. Anderson and Michael R. hoane * 1Restorative Neuroscience Laboratory; Center for Integrative Research in Cognitive and Neural sciences; Department of psychology; southern Illinois University; Carbondale, IL UsA; 2 Department of pharmacy; University of Washington; seattle, WA UsA Key words: neurorehabilitation, therapy, brain injury, behavior, restorative neurology Abbreviations: TBI, traumatic brain injury; CCI, cortical contusion injury; NAM, nicotinamide; MWM, morris water maze; + PARP, poly-ADP-ribose polymerase; NAD , nicotinamide adenine dinucleotide; BBB, blood-brain barrier; ATP, adenosine triphosphate; FPI, fluid percussion injury; ANOVA, analysis of variance; ad lib, ad libitum previously, we have demonstrated that nicotinamide (NAM), a neuroprotective soluble B-group vitamin, improves recovery of function following traumatic brain injury (TBI). however, no prior studies have examined whether NAM is beneficial following continuous infusions over 7 days post-TBI. The purpose of this study was to investigate the preclinical efficacy of NAM treatment as it might be delivered clinically; over severa