swimming exercise in the acute or late phase after sciatic nerve crush accelerates nerve regeneration游泳锻炼后的急性或晚期阶段坐骨神经粉碎加速神经再生.pdfVIP

Hindawi Publishing Corporation Neural Plasticity Volume 2011, Article ID 783901, 8 pages doi:10.1155/2011/783901 Research Article Swimming Exercise in the Acute or Late Phase after Sciatic Nerve Crush Accelerates Nerve Regeneration Rosana Macher Teodori,1 Joice Betini,2 Larissa Salgado de Oliveira,1 Luciane Lobato Sobral,1 Sibele Yoko Mattozo Takeda,1 and Maria Imaculada de Lima Montebelo1 1 Master’s Program in Physioterapy, Neuromuscular Plasticity Laboratory, FACIS, Methodist University of Piracicaba, 13400-911 Piracicaba, SP, Brazil 2 FACIS, Universidade Metodista de Piracicaba, 13400-911 Piracicaba, SP, Brazil Correspondence should be addressed to Rosana Macher Teodori, rteodori@unimep.br Received 29 December 2010; Revised 6 March 2011; Accepted 23 May 2011 Academic Editor: Lumy Sawaki Copyright © 2011 Rosana Macher Teodori et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. There is no consensus about the best time to start exercise after peripheral nerve injury. We evaluated the morphological and functional characteristics of the sciatic nerves of rats that began to swim immediately after crush nerve injury (CS1), those that began to swim 14 days after injury (CS14), injured rats not submitted to swimming (C) and uninjured rats submitted to swimming (S). After 30 days the number of axons in CS1 and CS14 was lower than in C (P 0.01). The diameter of axons and nerve fibers was larger in CS1 (P 0.01) and CS14 (P 0.05) than in C, and myelin sheath thickness was lower in all crushed groups (P 0.05). There was no functional difference between CS1 and CS14 (P 0.05). Sw