symptomatic therapy and rehabilitation in primary progressive multiple sclerosis有症状的治疗和康复的主要进展型多发性硬化症.pdfVIP

Hindawi Publishing Corporation Neurology Research International Volume 2011, Article ID 740505, 22 pages doi:10.1155/2011/740505 Review Article Symptomatic Therapy and Rehabilitation in Primary Progressive Multiple Sclerosis Fary Khan,1 Bhasker Amatya,2 and Lynne Turner-Stokes3 1 Department of Medicine, Dentistry and Health Sciences at The University of Melbourne, Royal Melbourne Hospital and Western Health, Rehabilitation Service—Royal Melbourne Hospital, Poplar Road, Parkville, Melbourne, VIC 3052, Australia 2 Department of Rehabilitation Medicine, Royal Melbourne Hospital, 34-54 Poplar Road Parkville, Melbourne, VIC 3052, Australia 3 Regional Rehabilitation Unit, Northwick Park Hospital, Watford Road, Harrow, Middlesex HA1 3UJ, UK Correspondence should be addressed to Fary Khan, fary.khan@.au Received 19 May 2011; Accepted 13 July 2011 Academic Editor: Peter van den Bergh Copyright © 2011 Fary Khan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system and a major cause of chronic neurological disability in young adults. Primary progressive MS (PPMS) constitutes about 10% of cases, and is characterized by a steady decline in function with no acute attacks. The rate of deterioration from disease onset is more rapid than relapsing remitting and secondary progressive MS types. Multiple system involvement at onset and rapid early progression have a worse prognosis. PPMS can cause significant disability and impact on quality of life. Recent studies are biased in favour of relapsing remitt