spectroscopic and physical–chemical characterization of ambazone–glutamate salt光谱和理化特性ambazone-glutamate盐.pdfVIP

Spectroscopy 26 (2011) 115–128 115 DOI 10.3233/SPE-2011-0519 IOS Press Spectroscopic and physical–chemical characterization of ambazone–glutamate salt Marieta Mure¸san-Pop a , Irina Kacsó b , Xenia Filip b , Emilia Vanea a , G. Borodi b , N. Leopold a , I. Bratu b,∗ and S. Simon a a Babe¸s-Bolyai University, Faculty of Physics, Cluj-Napoca, România b National Institute for RD of Isotopic and Molecular Technologies, Cluj-Napoca, România Abstract. Ambazone monohydrate C H N S · H O (AMB), a well-known antimicrobial compound, was used together with 8 11 7 2 Glutamic Acid C H NO (Glu) to obtain a new solid form using the solvent-drop grinding procedure. The screening of the new 5 9 4 solid form was best achieved by the combined use of X-ray Powder Diffraction (XRPD) and several spectroscopic techniques 13 (Fourier Transformed Infrared Spectroscopy (FTIR), X-ray Photoelectron Spectroscopy (XPS), Raman and C-NMR spec- troscopy) together with Differential Scanning Calorimetry (DSC), Differential thermal analysis and thermogravimetry (DTA– TGA). The combination of the mentioned analytical techniques allows the compound to be assigned to an ambazone–glutamate salt which crystallizes in monoclinic system having the following lattice parameters: a = 9.8352, b = 4.7014, c = 40.0987 Å and β = 94.505◦ . DSC, TGA data and the before mentioned spectroscopic techniques support the ambazone–glutamate salt formation. Keywords: Ambazone, glutamic acid, XRPD, DTA–TGA, DSC, FTIR, XPS, Raman, NMR, ambazone–glutamate salt 1. Introduction The most active areas of modern solid state chemistry represent the identification and characteriza- tion of different crystal f