semecarpus anacardium (bhallataka) alters the glucose metabolism and energy production in diabetic ratssemecarpus anacardium(bhallataka)改变糖尿病大鼠的葡萄糖代谢和能源生产.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2011, Article ID 142978, 9 pages doi:10.1155/2011/142978 Research Article Semecarpus anacardium (Bhallataka) Alters the Glucose Metabolism and Energy Production in Diabetic Rats Jaya Aseervatham,1 Shanthi Palanivelu,2 and Sachdanandam Panchanadham1 1 Department of Medical Biochemistry, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India 2 Department of Pathology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India Correspondence should be addressed to Sachdanandam Panchanadham, psachdanandam2000@ Received 12 March 2010; Revised 11 May 2010; Accepted 27 June 2010 Copyright © 2011 Jaya Aseervatham et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Glucose produced by gluconeogenesis and glycogenolysis plays an important role in aggravating hyperglycemia in diabetes, and altered mitochondrial function is associated with impaired energy production. The present study focuses on the effect of Semecarpus anacardium on carbohydrate metabolism and energy production in diabetic rats. Diabetes was induced by the administration of Streptozotocin at a dose of 50 mg/kg.b.wt. Three days after the induction, Semecarpus anacardium at a dose of 300 mg/kg.b.wt was administered for 21 days. After the experimental duration, the activities of the enzymes involved in Glycolysis, TCA cycle, gluconeogenesis, and glycogen were assayed in the li