the coexpression of reelin and neuronal nitric oxide synthase in a subpopulation of dentate gyrus neurons is downregulated in heterozygous reeler micereelin coexpression和神经元一氧化氮合酶在一个族群的齿状回神经元中表达下调杂合的卷取机老鼠.pdfVIP

Hindawi Publishing Corporation Neural Plasticity Volume 2010, Article ID 130429, 10 pages doi:10.1155/2010/130429 Research Article The Coexpression of Reelin and Neuronal Nitric Oxide Synthase in a Subpopulation of Dentate Gyrus Neurons Is Downregulated in Heterozygous Reeler Mice ´ 1 1 2 Raquel Romay-Tallon, Iria G. Dopeso-Reyes, April L. Lussier, Lisa E. Kalynchuk,2 and Hector J. Caruncho1 1 Biofarma Research Group, Department of Cell Biology, Faculty of Biology, University of Santiago de Compostela, Santiago de Compostela, 15782 Galicia, Spain 2 Neural Systems and Plasticity Research Group, Department of Psychology, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E5 Correspondence should be addressed to Hector J. Caruncho, hectorjuan.caruncho@usc.es Received 4 May 2010; Revised 4 August 2010; Accepted 11 August 2010 Academic Editor: Anna Braun ´ Copyright © 2010 Raquel Romay-Tallon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Reelin is an extracellular matrix protein expressed in several interneuron subtypes in the hippocampus and dentate gyrus. Neuronal nitric oxide synthase (nNOS) is also expressed by interneurons in these areas. We investigated whether reelin and nNOS are co- localized in the same population of hippocampal interneurons, and whether this colocalization is altered in the heterozygous reeler mouse. We found colocalization of nNOS in reelin-positive cells in the CA1 strat