the diagnostic value of the interstitial biomarkers kl-6 and sp-d for the degree of fibrosis in combined pulmonary fibrosis and emphysema间质生物标志物的诊断价值kl-6和sp-d纤维化的程度合并肺纤维化和肺气肿.pdfVIP

Hindawi Publishing Corporation Pulmonary Medicine Volume 2012, Article ID 492960, 6 pages doi:10.1155/2012/492960 Research Article The Diagnostic Value of the Interstitial Biomarkers KL-6 and SP-D for the Degree of Fibrosis in Combined Pulmonary Fibrosis and Emphysema Shigeki Chiba,1 Hiromitsu Ohta,1 Kyoko Abe,1 Shu Hisata,1 Shinya Ohkouchi,1 Yasushi Hoshikawa,2 Takashi Kondo,2 and Masahito Ebina1 1 Department of Pulmonary Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan 2 Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan Correspondence should be addressed to Hiromitsu Ohta, hirooota4793@ Received 4 November 2011; Accepted 22 December 2011 Academic Editor: Minoru Kanazawa Copyright © 2012 Shigeki Chiba et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The combined pulmonary fibrosis and emphysema (CPFE) was reported first in 1990, but it has been comparatively underestimated until recently. Although the diagnostic findings of both emphysematous and fibrotic regions are detectable by high- resolution computed tomography (HRCT) of the chest, the degree of progressive fibrosis, which increases with emphysematous lesions, is difficult to evaluate. In this study, we hypothesized that the biomarkers for pulmonary fibrosis, surfactant protein D (SP- D), and KL-6 would serve as good indicators of fibrotic lesions in CPFE. We recruited 46 patients who had been diagnosed in our hospital with both emphysema and fibrosis by their CT scan image from April 2003 to March 2008. The correlation among their