surgical treatment by partial petrosectomy for a middle-ear carcinoid with progressive extension a case report and review of the literature手术治疗部分petrosectomy中耳类癌瘤的进步扩展一个病例报告和文献之回顾.pdfVIP

Hindawi Publishing Corporation International Journal of Otolaryngology Volume 2010, Article ID 818673, 5 pages doi:10.1155/2010/818673 Case Report Surgical Treatment by Partial Petrosectomy for a Middle-Ear Carcinoid with Progressive Extension: A Case Report and Review of the Literature Mitsuhiro Aoki,1 Keisuke Mizuta,1 Natsuko Ueda,1 Nansei Yamada,1 Yatsuji Ito,1 Hiroki Kato,2 and Yoshinobu Hirose3 1 Department of Otolaryngology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu City 501-1194, Japan 2 Department of Radiology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu City 501-1194, Japan 3 Department of Tumor Pathology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu City 501-1194, Japan Correspondence should be addressed to Mitsuhiro Aoki, aoki@gifu-u.ac.jp Received 25 February 2010; Revised 17 April 2010; Accepted 20 April 2010 Academic Editor: Bill Yates Copyright © 2010 Mitsuhiro Aoki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We herein report a 59-year-old male patient with a recurrent carcinoid tumor of the middle ear 7 years after a tympanomastoidectomy. The CT and dynamic MRI demonstrated an extensive tumor close to the carotid artery canal and the jugular bulb, and the tumor was removed by a partial petrosectomy with a transmastoid approach. The histopathological findings revealed a solid and trabecular tumor with cells positive for cytokeratin, chromogranin A, synaptophysin, and CD56. The MIB-1 antibody for the Ki-67 antigen was positive in 6.6% of the tumor cells. The relevant literature is reviewed in regard to the p