specific and nonhomologous isofunctional enzymes of the genetic information processing pathways as potential therapeutical targets for tritryps具体nonhomologous isofunctional酶的基因信息处理通路作为tritryps潜在的治疗目标.pdfVIP

SAGE-Hindawi Access to Research Enzyme Research Volume 2011, Article ID 543912, 8 pages doi:10.4061/2011/543912 Research Article Specific and Nonhomologous Isofunctional Enzymes of the Genetic Information Processing Pathways as Potential Therapeutical Targets for Tritryps ˜ 1, 2 ˜ 2 ´ 1 Monete Rajao Gomes, Ana Carolina Ramos Guimaraes, and Antonio Basılio de Miranda 1 Laboratorio de Biologia Computacional e Sistemas, Instituto Oswaldo Cruz/FIOCRUZ, 21045-900 Rio de Janeiro, RJ, Brazil ´ 2 Laboratorio de Genomica Funcional e Bioinformatica, Instituto Oswaldo Cruz/FIOCRUZ, 21045-900 Rio de Janeiro, RJ, Brazil ´ ˆ ´ ˜ Correspondence should be addressed to Ana Carolina Ramos Guimaraes, carolg@fiocruz.br Received 15 January 2011; Revised 22 March 2011; Accepted 5 May 2011 Academic Editor: Ariel M. Silber ˜ Copyright © 2011 Monete Rajao Gomes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Leishmania major, Trypanosoma brucei, and Trypanosoma cruzi (Tritryps) are unicellular protozoa that cause leishmaniasis, sleeping sickness and Chagas’ disease, respectively. Most drugs against them were discovered through the screening of large numbers of compounds against whole parasites. Nonhomologous isofunctional enzymes (NISEs) may present good op