specific factors influence the success of autologous and allogeneic hematopoietic stem cell transplantation具体因素影响自体和同种异体造血干细胞移植的成功.pdfVIP

[Oxidative Medicine and Cellular Longevity 2:2, 82-87; April/May/June 2009]; ©2009 Landes Bioscience Research Paper Specific factors influence the success of autologous and allogeneic hematopoietic stem cell transplantation Thissiane L. Gonçalves,* Dalila M. Benvegnú and Gabriela Bonfanti Departamento de Análises Clínicas e Toxicológicas; CCS; Universidade Federal de Santa Maria; Santa Maria RS, Brazil Abbreviations: AA, aplastic anemia; BCNU, carmustine; BMT, bone marrow transplantation; CR, conditioning regimen; G-CSF, gran- ulocyte-colony-stimulating factor; GVHD, graft-versus-host disease; HSCT, hematopoietic stem cell transplantation; M-200, melphalan; MM, multiple myeloma; OS, overall survival; PBSCT, peripheral blood stem cell transplantation; SMD, syndrome myelodysplastic; TBI, total body irradiation; VP-16, etoposide Key words: engraftment, hematopoietic stem cell transplantation, peripheral blood stem cell transplantation, bone marrow transplanta- tion, conditioning regimen Successful hematopoietic stem cell transplantation (HSCT), hematologic, immunologic and genetic diseases.1 This therapy both autologous and allogeneic, requires a rapid and durable consists of the intravenous infusion of hematopoietic progenitor engraftment, with neutrophil (500/μL) and platelet (20,000/ cells to reestablish marrow function in patients with damaged or μL) reconstitution. Factors influencing engraftment after autolo- defective bone marrow. Allogeneic HSCT involves the transfer of gous or allogeneic HSCT were investigated in 65 patients: 25 marrow from a donor to another person. It has been preferentially autologous peripheral stem cell transplantation (PBSCT) and 40 performed in patients with under 60 years of age, because of a higher allogen