the effect of arterial ph on oxygenation persists even in infants treated with inhaled nitric oxide动脉ph值对氧化的影响持续甚至在婴儿吸入一氧化氮处理.pdfVIP

Hindawi Publishing Corporation Pulmonary Medicine Volume 2011, Article ID 189205, 6 pages doi:10.1155/2011/189205 Research Article The Effect of Arterial pH on Oxygenation Persists Even in Infants Treated with Inhaled Nitric Oxide Aimee M. Barton,1 M. Kabir Abubakar,1 Jennifer Berg,1 and Martin Keszler2 1 Department of Pediatrics, Georgetown University Hospital, 3800 Reservoir Road NW, M3400, Washington, DC 20007, USA 2 Department of Pediatrics, Women and Infants Hospital, 101 Dudley Street, Providence, RI 02905, USA Correspondence should be addressed to Aimee M. Barton, amg57@ Received 22 January 2011; Accepted 6 May 2011 Academic Editor: Irwin Reiss Copyright © 2011 Aimee M. Barton et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective. To validate the empiric observation that pH has an important effect on oxygenation in infants receiving iNO. Study Design. Demographics, ventilator settings, arterial blood gases (ABG), and interventions for up to 96 hours of life were extracted from the charts of 51 infants receiving iNO. Need for ECMO and survival to discharge were noted. Mean blood pressure (MBP) and mean airway pressure (MAP) were recorded. The arterial/alveolar (a/A) ratio was used as the primary outcome. Analysis was by simple linear regression and multiple linear regression analyses and Fisher’s exact test. pH responsiveness was arbitrarily defined as a correlation coefficient (CC) of 0.40 with P 0.05. Results. Mean gestational age was 38.8 weeks and mean birth weight was 3300 g. All patients had clinical diagnosis of PPHN. Clear responsiveness to pH was found in 31/51 infants.