the potential applications of peroxisome proliferator-activated receptor ligands in assisted reproductive technology过氧物酶体的潜在应用proliferator-activated受体配体在辅助生殖技术.pdfVIP

Hindawi Publishing Corporation PPAR Research Volume 2008, Article ID 794814, 6 pages doi:10.1155/2008/794814 Review Article The Potential Applications of Peroxisome Proliferator-Activated Receptor δ Ligands in Assisted Reproductive Technology Jaou-Chen Huang Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology Reproductive Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA Correspondence should be addressed to Jaou-Chen Huang, jaou-chen.huang@ Received 13 May 2008; Revised 27 June 2008; Accepted 12 September 2008 Recommended by Francine M. Gregoire Peroxisome proliferator-activated receptor δ (PPARδ, also known as PPARβ ) has ubiquitous distribution and extensive biological functions. The reproductive function of PPARδ was first revealed in the uterus at the implantation site. Since then, PPARδ and its ligand have been discovered in all reproductive tissues, including the gametes and the preimplantation embryos. PPARδ in preimplantation embryos is normally activated by oviduct-derived PPARδ ligand. PPARδ activation is associated with an increase in embryonic cell proliferation and a decrease in programmed cell death (apoptosis). On the other hand, the role of PPARδ and its ligand in gamete formation and function is less well understood. This review will summarize the reproductive functions of PPARδ and project its potential applications in assisted reproductive technology. Copyright © 2008 Jaou-Chen Huang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 1. INTRODUCTION /ART/ART2005/sect2 fig5-15.ht