the clinical and prognostic significance of activated akt-mtor pathway in human astrocytomas的临床和预后意义激活akt-mtor通路在人类星形细胞瘤.pdfVIP

Hindawi Publishing Corporation Neurology Research International Volume 2012, Article ID 454957, 13 pages doi:10.1155/2012/454957 Review Article The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas Elias A. El Habr,1 Christos Adamopoulos,2 Georgia Levidou,1 Aggeliki A. Saetta,1 Penelope Korkolopoulou,1 and Christina Piperi2 1 First Department of Pathology, Laiko Hospital, National and Kapodistrian University of Athens Medical School, 11527 Athens, Greece 2 Department of Biological Chemistry, National and Kapodistrian University of Athens Medical School, 11527 Athens, Greece Correspondence should be addressed to Elias A. El Habr, elhabere@ Received 30 July 2011; Revised 5 December 2011; Accepted 9 December 2011 Academic Editor: Stuart Burri Copyright © 2012 Elias A. El Habr et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Astrocytomas, the most common type of gliomas, and especially grade IV glioblastomas are “endowed” with strong proliferation and invasion potentials, high recurrence rate, and poor patients’ prognosis. Aberrant signaling of AKT-mTOR (mammalian target of rapamycin) has been implicated in carcinogenesis. This paper is focused on the impact of deregulated AKT-mTOR signaling components in the clinical outcome and prognosis of human astrocytomas. Current therapeutic targeting of astrocytomas with AKT-mTOR inhibitors in preclinical and clinical stage is also discussed, including future perspectives regarding the management of these devastating tumors. 1. Introduction critically d