the chinese herbal decoction danggui buxue tang inhibits angiogenesis in a rat model of liver fibrosis中国草药汤danggui buxue唐抑制血管生成在肝纤维化大鼠模型.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 284963, 11 pages doi:10.1155/2012/284963 Research Article The Chinese Herbal Decoction Danggui Buxue Tang Inhibits Angiogenesis in a Rat Model of Liver Fibrosis Jing Lv,1 Zhimin Zhao,1 Yuan Chen,1 Qinglan Wang,1 Yanyan Tao,1 Li Yang,2 Tai-Ping Fan,3 and Chenghai Liu1, 4, 5 1 Institute of Liver Diseases, ShuGuang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China 2 The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China 3 Angiogenesis Chinese Medicine Laboratory, Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK 4 E-Institute of TCM Internal Medicine, Shanghai Municipal Education Commission, Shanghai 201203, China 5 Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai 201203, China Correspondence should be addressed to Tai-Ping Fan, tpf1000@cam.ac.uk and Chenghai Liu, chenghai liu@ Received 20 February 2012; Revised 13 May 2012; Accepted 14 May 2012 Academic Editor: Chang-Quan Ling Copyright © 2012 Jing Lv et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In this study, we investigated the anti-angiogenic effect of the Chinese herbal decoction Danggui Buxue Tang (DBT; Radix Astragali and Radix Angelicae sinensis in 5 : 1 ratio) in a rat model of liver fibrosis, in order to elucidate its mechanisms of acti