the chick chorioallantoic membrane a model of molecular, structural, and functional adaptation to transepithelial ion transport and barrier function during embryonic development小鸡绒毛膜尿囊的膜的分子模型,结构和功能适应transepithelial离子运输和障碍函数在胚胎发育期间.pdfVIP

Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2010, Article ID 940741, 12 pages doi:10.1155/2010/940741 Review Article The Chick Chorioallantoic Membrane: A Model of Molecular, Structural, and Functional Adaptation to Transepithelial Ion Transport and Barrier Function during Embryonic Development Maria Gabriella Gabrielli and Daniela Accili Department of Comparative Morphology and Biochemistry, University of Camerino, Via Gentile III da Varano, 62032 Camerino, Italy Correspondence should be addressed to Maria Gabriella Gabrielli, gabriella.gabrielli@unicam.it Received 21 July 2009; Revised 16 November 2009; Accepted 6 January 2010 Academic Editor: Amanda McCann Copyright © 2010 M. G. Gabrielli and D. Accili. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The chick chorioallantoic membrane is a very simple extraembryonic membrane which serves multiple functions during embryo development; it is the site of exchange of respiratory gases, calcium transport from the eggshell, acid-base homeostasis in the embryo, and ion and H2 O reabsorption from the allantoic fluid. All these functions are accomplished by its epithelia, the chorionic and the allantoic epithelium, by differentiation of a wide range of structural and molecular peculiarities which make them highly specialized, ion transporting epithelia. Studying the different aspects of such a developmental strategy emphasizes the functional potential of the epithelium and offers an excellent model system to gain insights into questions partly still unresolved. 1. Introduction decades