the possible role of epigenetics in gestational diabetes cause, consequence, or both表观遗传学在妊娠期糖尿病引起的可能的作用,因此,或两者兼而有之.pdfVIP

Hindawi Publishing Corporation Obstetrics and Gynecology International Volume 2010, Article ID 605163, 7 pages doi:10.1155/2010/605163 Review Article The Possible Role of Epigenetics in Gestational Diabetes: Cause, Consequence, or Both ´ 1 ´ 2 ´ 1 3 J. L. Fernandez-Morera, S. Rodrıguez-Rodero, E. Menendez-Torre, and M. F. Fraga 1 Endocrinology and Nutrition Service, Hospital Universitario Central de Asturias, Av. Julian Claverıa s/n, 33006 Oviedo, Spain ´ 2 Cancer Epigenetics Laboratory, Instituto Universitario de Oncologıa del Principado de Asturias (IUOPA), Universidad de Oviedo, ´ HUCA, 33006 Oviedo, Spain 3 Department of Immunology and Oncology, National Center for Biotechnology, CNB-CSIC, Cantoblanco, 28049 Madrid, Spain Correspondence should be addressed to M. F. Fraga, mffraga@cnb.csic.es Received 23 February 2010; Accepted 22 August 2010 Academic Editor: Julian T. Parer ´ Copyright © 2010 J. L. Fernandez-Morera et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Gestational diabetes mellitus (GDM) is defined as the glucose intolerance that is not present or recognized prior to pregnancy. Several risk factors of GDM depend on environmental factors that are thought to regulate the genome through epigenetic