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Hindawi Publishing Corporation Parkinson’s Disease Volume 2012, Article ID 938528, 16 pages doi:10.1155/2012/938528 Research Article The Protective Effect of Minocycline in a Paraquat-Induced Parkinson’s Disease Model in Drosophila is Modified in Altered Genetic Backgrounds Arati A. Inamdar,1, 2 Anathbandhu Chaudhuri,1, 3 and Janis O’Donnell1 1 Department of Biological Sciences, University of Alabama, Tuscaloosa, AL 35487-0344, USA 2 Department of Plant Biology and Pathology, Rutgers University-The State University of New Jersey, Room 291D, Foran Hall, 59 Dudley Road, New Brunswick, NJ 08901, USA 3 Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA Correspondence should be addressed to Arati A. Inamdar, inamdar@ Received 10 January 2012; Accepted 4 June 2012 Academic Editor: Katerina Venderova Copyright © 2012 Arati A. Inamdar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Epidemiological studies link the herbicide paraquat to increased incidence of Parkinson’s disease (PD). We previously reported that Drosophila exposed to paraquat recapitulate PD symptoms, including region-specific degeneration of dopaminergic neurons. Minocycline, a tetracycline derivative, exerts ameliorative effects in neurodegenerative disease models, including Drosophila. We investigated whether our environmental toxin-based PD model could contribute to an understanding of cellular and genetic mechanisms of minocycline action and whether we could assess potential interference with these drug effects in altered genetic