the diabetic nephropathy and the development of hypertension in rats糖尿病肾病和高血压大鼠的发展.pdfVIP

Int. Jnl. Experimental Diab. Res., Vol. 2, pp. 195-199 (C) 2001 OPA (OverseasPublishers Association) N.V. Reprints available directly from the publisher Published by license under Photocopying permitted by license only the Harwood Academic Publishers imprint, part of Gordon and Breach Publishing, member of the Taylor Francis Group. Printed in the U.S.A. The Diabetic Nephropathy and the Development of Hypertension in Rats ADRIANA ZUCCOLLO MONICANAVARROb and ORLANDO CATANZAROa,* b, apROSIVAD-CONICET, Catedra de Animales de Laboratorio, Facultad de Farmacia y Bioquimica-UBA; DpROSIVAD-CONICET, Instituto Universitario de Ciencias de la Salud. Facultad de Medicina-Fundacion Barcelo (Received May 2001; Infinalform 25 June 2001) The present study was designed to examine the de- and hypertension are common chronic conditions velopment of hypertension in diabetic rats treated which frequently coexist. According to Viberti with streptozotocin (STZ, lmg/g bw). The rats were et a/. [2] the progression of diabetic nephropathy studied at 3, 6, 9, 12 and 15 weeks. From the third week the rats were divided in diabetic rats according appears to be closely related to blood pressure ele- their glycemias and controls, along 15 weeks. After vation. Several studies show that the measure of the third week a group of rats showed increased uri- urinary protein loss correlates with the rate of na