the relation between histological, tumor-biological and clinical parameters in deep and superficial leiomyosarcoma and leiomyoma组织之间的关系,肿瘤生物学和临床参数的深和表面的平滑肌肉瘤和平滑肌瘤.pdfVIP

Sarcoma (2002) 6, 105–110 ORIGINAL ARTICLE The relation between histological, tumor-biological and clinical parameters in deep and super cial leiomyosarcoma and leiomyoma 1 1 1 JUSTIN PIJPE , GERBEN H. TORN BROERS , BOUDEWIJN E.CH. PLAAT , 2 2 1 3 M. HUNDEIKER , F. OTTO , MIRJAM F. MASTIK , HARALD J. HOEKSTRA , 4 5 WINETTE T.A.VAN DER GRAAF , EVA VAN DEN BERG WILLEMINA M. MOLENAAR1 1 3 4 5 Departments of Pathology, Surgical Oncology, Medical Oncology and Medical Genetics, University Hospital of 2 1 Groningen, Groningen,The Netherlands, Fachklinik Hornheide, Münster, Germany 1 1 Abstract Purpose: Leiomyosarcomas (LMS) of deep and super cial tissues were examined to identify prognostic markers explaining their different biological behaviour and to de ne differences between cutaneous and subcutaneous LMS. LMS and leiomy- omas (LM) of the skin were compared to nd consistent differences that could aid in the (sometimes dif cult) diagnosis. Patients: Material was obtained from 27 patients with a deep LMS, 14 with a super cial LMS, and 21 with a LM. Methods: Proliferation markers (mitotic and Ki-67 indices), DNA ploidy, size, grade, and the amount of apoptosis were studied. Statistical analysis was performed and survival curves were constructed by the Kaplan-Meier method and compared by the log-rank test. Results: Super ci