the dynamics of oxidized ldl during atherogenesis氧化低密度脂蛋白在动脉粥样化形成的动力.pdfVIP

Hindawi Publishing Corporation Journal of Lipids Volume 2011, Article ID 418313, 9 pages doi:10.1155/2011/418313 Review Article The Dynamics of Oxidized LDL during Atherogenesis Hiroyuki Itabe, Takashi Obama, and Rina Kato Department of Biological Chemistry, Showa University School of Pharmaceutical Sciences, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan Correspondence should be addressed to Hiroyuki Itabe, h-itabe@pharm.showa-u.ac.jp Received 17 January 2011; Accepted 9 March 2011 Academic Editor: Angeliki Chroni Copyright © 2011 Hiroyuki Itabe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Accumulating evidence indicates that oxidized low-density lipoprotein (OxLDL) is a useful marker for cardiovascular disease. The uptake of OxLDL by scavenger receptors leads to the accumulation of cholesterol within the foam cells of atherosclerotic lesions. OxLDL has many stimulatory effects on vascular cells, and the presence of OxLDL in circulating blood has been established. According to the classical hypothesis, OxLDL accumulates in the atherosclerotic lesions over a long duration, leading to advanced lesions. However, recent studies on time-course changes of OxLDL in vivo raised a possibility that OxLDL can be transferred between the lesions and the circulation. In this paper, the in vivo dynamics of OxLDL are discussed. 1. The Background of OxLDL Hypothesis modified LDL. More than 10 scavenger receptors have been identified so far [ 11– 13]. In the last three decades, a large volume of studies hav