试验兔钝性肝损伤MR体素内不相干运动IVIM价值的初探.DOC

实验兔钝性肝损伤MR体素内不相干值 赖清泉，黄启明，黄芳，李，黄 福建医科大学附属第二医院，中山北路34泉州362000， 黄启明内容摘要 使用相干（IVIM）材料与方法GE1.5T- HDXT磁共振扫描仪行弥散加权成像（DWI）IVIM序列扫描。IVIM厚为4mm，1mm.扫描IVIM软件处理IVIM成像后，测量标准的ADC，慢ADC，快ADC和快ADC分数，没有正常组织对比度信号区域 结果组标准的ADC，慢ADC，快ADC和快ADC分数分别为3.55±0.26）×10 ﹣3平方毫米/秒，（2.73±0.22）×10 ﹣3平方毫米/秒，（1.89±0.20）× 10﹣2平方毫米/秒，36.5±3.94，而在正常肝组分别为（2.65±0.23）×10 ﹣3平方毫米/秒，（1.07±0.26）×10﹣3平方毫米/秒，（3.50±0.28）× 10﹣2平方毫米/ s和51.5±1.29，标准的ADC，ADC及快ADC组间差异有统计学意义（P 0.0），但快ADC分数的差异无统计学意义（P 0.0）结论 IVIM参数能够反映弥散灌注，这可能提供病灶的信息。 关键词相干Intravoxel Incoherent Motion Diffusion-weighted MR Imaging for Characterization of Hepatic Injury in Rabbit Qingquan Lai, Qiming Huang，Huang fang，Wu hong，Li weicheng， Huang wenhan The Department of Radiology, Second Affiliated Hospital of Fujian Medical University, 34 Zhongshan Bei Road, Quanzhou 362000, China Abstract Objectives To evaluate the potential value of?intravoxel?incoherent?motion ?(IVIM) in the assessment of hepatic injury in rabbit. Materials and Methods MR imaging data of 10 rabbits with hepatic injury confirmed by anatomy and 10 rabbits of normal liver tissue were analyzed retrospectively.All animal underwent routine liver MRI sequences,including T1WI,T2WI,DWI and IVIM sequence..The standard ADC,slow ADC,fast ADC and fraction of fast ADC values of hepatic injury and normal groups were measured and analyzed by using t test. Results The standard ADC,slow ADC,fast ADC and fraction of fast ADC of hepatic injury group were （0.26） （0.22） （）（0.23）, （0.26） （）0.05).There was no difference of fraction of fast ADC between the two groups. Conclusion IVIM parameters can reflect diffusion and perfusion of hepatic injury. It may play a complementary role in the diagnosis and has some application prospects. Key Words Hepatic injury；Intravoxel incoherent motion; Magnetic resonance imaging 随着近年来对于体素内不相干IVIM）序列应用的开展，体素内不相干IVIM研究尚还未见报道，作为新的序列，本文通过钝性肝损伤的动物模型，进行IVIM序列扫描测量和初步分析预期肝脏损伤尤其是挫伤得出一个定量的标准，为临床诊疗提供依据。 1.资料与方法 资料及动物模型 自制BIM2型生物撞击机[4] ，器械有19G静脉穿刺针、剪刀、台秤、无齿镊、光学显微镜、消毒平及消毒剂。新西兰大白兔12