雾化吸入普米克令舒药物治疗小儿急性感染性喉炎患-安徽医药杂志社.DOC

雾化吸入布地奈德治疗小儿急性感染性喉炎的临床疗效及安全性评价 杨秋丽 郑小翠 [摘要] 目的 探究小儿急性感染性喉炎采用雾化吸入布地奈德混悬液治疗的临床疗效及对IL-4、IL-8、IFN-γ和IgE水平的影响。方法 将2011年1月至2015年1月我院小儿急性感染性喉炎110例患儿，随机分组，各55例，两组均给予常规对症治疗，对照组加用雾化吸入地塞米松治疗，观察组加用雾化吸入布地奈德混悬液治疗，对比两组临床疗效、症状改善情况以及不良反应情况，并检测对比两组IL-4（白细胞介素-4）、IL-8(白细胞介素-8)、IFN-γ（干扰素γ）和IgE（免疫球蛋白E）水平。结果 治疗后观察组病程持续时间、症状改善情况及住院时间与对照组比较，明显缩短，差异有统计学意义（P＜0.05）；观察组疗效（96.36%）与对照组（76.36%）相比，优势明显，差异有统计学意义（P＜0.01），且两组均未发现明显药物不良反应。结论 小儿急性感染性喉炎采用雾化吸入布地奈德混悬液治疗效果显著，能有效改善患儿临床症状，改善IL-4、IL-8、IFN-γ和IgE水平，且具有较高的安全性，值得推广。 [关键词] 布地奈德; 雾化; 吸入; 小儿急性感染性喉炎；疗效 Clinical efficacy of atomizing inhalation of Budesonide suspension therapy and safety evaluation of treatment on children with acute infectious laryngitis [Abstract] Objective To investigate the clinical curative effect of Budesonide suspension on children acute infectious laryngitis disease through atomization inhalation therapy and the impact on IL-4 and IL-8 and IFN - and IgE levels during therapy. Methods 110 children with acute infectious laryngitis during January 2011 to January 2015 in our hospital were randomly divided into two groups and given conventional symptomatic treatment. The control group 55 cases were treated with dexamethasone inhalation, while the observation group 55 cases were treated with Budesonide suspension. We compared clinical curative effect, including remission of symptoms and adverse reaction, and detected IL-4 (interleukin-4 ), IL-8 (interleukin IL-8), interferon gamma (IFN-γ) and IgE (immunoglobulin E) levels. Results No obvious adverse drug reaction was found in both group. However, compared with control group, the Budesonide suspension treatment improved remission of symptoms, and shortened disease duration and hospitalization time, which was statistically significant (P 0.05). The observation group represented advantage on clinical efficacy, which showed higher clinical efficacy (96.36%) than the control group (76.36%) （P＜0.01）. Conclusion It is remarkable that utilizing Budesonide suspension atomization inhalat