NMDA受体在痛觉过敏中的作用-生命科学.PDF

18 1 Vol. 18, No. 1 2006 2 Chinese Bulletin of Life Sciences Jan., 2006 1004-0374(2006)01-0000-00 NMDA 300 070 N - -D- (NMDA ) w i n d -u p N MD A N - - D - R 96 2 A Effects of NMDA receptors on hyperalgesia CHEN Fei, FANG Bu-Wu (Department of Pharmacology, Tianjin Medical University, Tinanjin 300070, China) Abstract: NMDA receptors are a subtype of excitatory transmitters-glutamate receptor in the central nervous system. They belong to ionotropic receptors and play an important role in many complex physiological and pathological processes, including wind-up, central sensitization, long-term potentiation, peripheral sensitization, visceral pain, cellular necrosis and apoptosis, as well as induction and maintenance of the hyperalgesia. Study on effects of NMDA receptors on hyperalgesia provides a wide strategy and prosperity for a novel class of analgesics. Key words: NMDA receptors; hyperalgesia; analgesia [3] NR 1 NR2A-D NR3A-B NMDA NR1 NR2 NR3 N- -D- NMDA NR1 NR2 NR3 Monyer [4]NR1 NMDA NR2A-D NMDA wind-up NR3 NMDA [1] [5] NR3A NR1 [2] NR2 NMDA NR3B NR1 NR2A NR3B 1NMDA NMDA NMDA NR1 2005-08-01 2005-09-21 ( 1 9 8 0 ) ( 1 9 6 2 ) * 2 Mg2+ NR2A NR2B 9- NMDA CA1 CA3 DG [6]; NR2C Kd NR2D NMDA [14] NR3A NR3B Mg2+ [3]