多囊卵巢综合征患者血清可溶性细胞间粘附分子-1水平与脂代谢情况的相关性研究.docVIP

多囊卵巢综合征患者血清可溶性细胞间粘附分子－1水平与脂代谢情况的相关性研究 黄卡立1，蒋凤艳 2，黎红芳 2 (1.广西壮族自治区人口和计划生育研究中心 南宁530021；2.广西医科大学 南宁530021） 【摘要】目的:探讨多囊卵巢综合征(PCOS)患者血清可溶性细胞间粘附分子－1（sICAM-1）水平与脂代谢情况的相关性,为PCOS患者心血管疾病的防治提供理论依据。方法:以体重指数(BMI)≥24kg/m2或腰臀比(WHR)≥0.8为肥胖标准,将96例PCOS患者分为肥胖A组和非肥胖A组、肥胖B组和非肥胖B组，测定sICAM-1、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白 A1(ApoA1)、载脂蛋白B(ApoB)、脂蛋白a（Lp-a）,并将sICAM-1与所测临床指标进行多因素分析。结果:1.肥胖A组血清sICAM-1水平高于非肥胖A组(p0.05)，肥胖B组血清sICAM-1水平高于非肥胖B组(p0.05)；2.PCOS 肥胖A组的TG明显高于非肥胖A组(p0.05)，肥胖B组的TC、LDL-C明显高于非肥胖B组(p0.05)；3.多因素分析显示血清sICAM-1水平与TC、LDL-C水平呈正相关。结论：PCOS患者血清sICAM-1水平及脂代谢异常与肥胖有密切联系，PCOS患者sICAM-1水平随着LDL-C水平、TC水平增高而升高。应积极治疗和监测PCOS肥胖患者,以防止和减少其心血管疾病的发生发展。 【关键词】多囊卵巢综合征；可溶性细胞间粘附分子－1；脂代谢；心血管疾病 The Associativity between Serum sICAM-1 and lipid metabolism in PCOS Patients HUANG Ka-Li1,JIANG Feng-Yan2,LI Hong-Fang2 (Research Center for Family Planning of Guangxi Zhuang Autonomous Region, Nanning Guangxi 530021,China;2 .Guangxi Medical University , Nanning Guangxi 530021,China) 【Abstract】Objective To research soluble intercellular adhesion molecule-1 (sICAM-1) concentration and lipid metabolism in polycystic ovary syndrome(PCOS), and to provide the basis for Prevention and treatment of cardiovascular disease in these women. Methods According to BMI≥24kg/m2 or WHR≥0.8,96 cases PCOS subject were devided into obese group-A、non- obese group-A、obese group-B、non- obese group-B.All the subject were measured the level of sICAM-1、Triglycerides(TG）、Total Cholesterol(TC）、High Density Lipoprotein Cholesterol(HDL-C）、Low Density Lipoprotein Cholesterol(LDL-C）、Apolipoprotein (a)-1(ApoA1）、Apolipoprotein(b) (ApoB）、Lipoprotein a(Lp-a）.The multipul linear regression analysis were done between sICAM-1 and clinical indexes above. Results 1.The sICAM-1level in obese group A was higher than non-obese group A(p0.05),and the sICAM-1level in obese group B was higher than non-obese group B (p0.05);2. The TG level in obese group A was higher than non- obese group A(p0.05), the TC and LDL-C