DESIGN ANALYSES OF CAPILLARY BURST （设计分析毛细管破裂）.pdfVIP

DESIGN ANALYSES OF CAPILLARY BURST VALVES IN CENTRIFUGAL MICROFLUIDICS Jun Zeng, Deb Banerjee, Manish Deshpande and John R. Gilbert Microcosm Technologies, 215 First Street, Cambridge MA 02142, USA David C. Duffy and Gregory J. Kellogg Gamera Bioscience, 200 Boston Ave., Medford, MA Abstract This paper presents current research in analysis of passive microfluidic capillary burst valves. A capillary burst valve stops the liquid flow using a capillary pressure barrier that develops when the channel cross section expands abruptly. Valves of this type provide the capability of precise control on sample location in microfluidic device. Detailed numerical analyses of the valve behaviour is presented and compared with experimental measurements. A model for the valve is then extracted that characterizes the valve performance for various common cross sections. Keywords: Micro fluid control, Valves, Capillary Gating, Centrifugal force, FlumeCAD I. Introduction There is a wide interest in micron-scale integrated chemical/biochemical analysis or synthesis systems, also referred to as lab-on-a-chip[1]. An essential ingredient in these devices is the ability to control the spatial and temporal position of the sample as it flows through the device. Conventional diaphragm valves can fulfil this task, but require both moving parts and an external actuation mechanism, often complicating the implementation and integration. Several methods of electrokinetically controlling the liquid flow have been demonstrated. These methods are however sensitive to the physicochemical properties of the components and by the presence of trapped air. An alternative approach presented in this paper uses a passive microfluid