Sulphoraphane, by virtue of its antioxidant （Sulphoraphane,由于其抗氧化剂）.pdfVIP

Int.J.Curr.Microbiol.App.Sci (2014) 3(1): 476-486 ISSN: 2319- 7706 Volume 3 Number 1 (2014) pp. 476-486 Original Research Article Sulphoraphane, by virtue of its antioxidant potential down-regulates HSP90 in leukemia cells 1 1 2 3 1* Ruma Sarkar , Apurba Mukherjee , Raj Biswas , Jaydip Biswas and Madhumita Roy 1Department Environmental Carcinogenesis Toxicology, Chittaranjan National Cancer Institute, 37, S P Mukherjee Road, Kolkata, India 2NSHM Knowledge Campus Kolkata (Group of Institutions), (WBUT), Kolkata, India 3Director, Chittaranjan National Cancer Institute, 37, S P Mukherjee Road, Kolkata 700026, India *Corresponding author A B S T R A C T Persistent pro-oxidative state leading to oxidative stress is a key feature of cancer cells. Cancer cells generate more reactive oxygen species (ROS) than their normal K e y w o r d s counterparts. Heat shock proteins (HSPs), which are a highly conserved family of proteins that aid in proper folding, are induced in response to various forms of Leukemia; stresses including oxidative stress. Of all types of HSPs, HSP90 play a pivotal role sulphoraphane; in the pathogenesis of cancer. Targeting ROS and HSP90 could be a novel ROS; approach in cancer control. Inhibitors used are generally toxic and therefore HSP90; adopting natural means in this regard is highly desirable. Isothiocyanates are a clas