神经突生长抑制（Neurite outgrowth inhibition）.doc

神经突生长抑制（Neurite outgrowth inhibition） Neurite outgrowth inhibition Update Date: 2010-08-04 Shen Qiang, Zhao Dinglin In recent years, some foreign scholars have taken the method of eliminating growth inhibition to explore new methods for repairing spinal cord injury. At present, there are at least two kinds of inhibitory factors: (1) inhibiting the motility of the growth cone; (2) destroying the stability of the growth cone and the base surface. In this review, we reviewed the experimental studies on neurite growth inhibition, and discussed the inhibitory factors of neurite outgrowth. (1) a nerve medium (specifically soluble molecules) that prevents growth cone growth In recent years, in vitro cultures of mammalian and snake cells have found that some specific soluble molecules apparently retract the cell growth cone. One of the most representative is the neurotransmitter, which includes 5-, serotonin, glutamate, dopamine, and acetylcholine. The inhibitory effect of medium on the growth of neural axon is related to its concentration, and confirmed as the receptor, the growth cone filopodia active termination of growth cone collapse structure [1, 2]. Two. Specific proteins that prevent growth cone growth It was found that some membrane glycoproteins specifically reject or inhibit neurite outgrowth. In the embryo after the half, the molecular weight into liposomes resulted in DRG cells cultured for 48000 and 55000 membrane glycoprotein (dorsal root ganglion cells) growth cone collapse; when given the Rabbit anti glycoprotein antibodies, growth cone collapse phenomenon is eliminated. In the optic tectum, 33000 molecular weight glycoprotein and lipid droplets combined with global action induced growth cone collapse 3, speculated that this molecule plays an important role in the development of visual cap formation. Recently, the molecular weight of extraction in adult chicken brain glycoprotein with 100000 Collapsin, which is composed of signal peptide, Semaphorin region,