红细胞膜脂肪酸成分、膜流动性改变与糖尿病视网膜病变的关系（The relationship between the changes of fatty acid composition and membrane fluidity of erythrocyte membrane and diabetic retinopathy）.docVIP

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红细胞膜脂肪酸成分、膜流动性改变与糖尿病视网膜病变的关系（The relationship between the changes of fatty acid composition and membrane fluidity of erythrocyte membrane and diabetic retinopathy）.doc

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红细胞膜脂肪酸成分、膜流动性改变与糖尿病视网膜病变的关系（The relationship between the changes of fatty acid composition and membrane fluidity of erythrocyte membrane and diabetic retinopathy）

红细胞膜脂肪酸成分、膜流动性改变与糖尿病视网膜病变的关系（The relationship between the changes of fatty acid composition and membrane fluidity of erythrocyte membrane and diabetic retinopathy） The relationship between the changes of fatty acid composition and membrane fluidity of erythrocyte membrane and diabetic retinopathy 2011-07-21 Yang Gangyi, Qiu Hongxin, Deng Huacong, Wang Shuping, Zhang Suhua [Objective] to investigate the relationship between the fatty acid composition and membrane fluidity of erythrocyte membrane and diabetic retinopathy (DR). Methods high performance liquid chromatography (HPLC) and fluorescence polarization technique were used to determine the content of erythrocyte membrane fatty acid and membrane viscosity in 29 normal subjects and 63 patients with non insulin dependent diabetes mellitus (NIDDM). The results of erythrocyte membrane in patients with NIDDM four arachidonic acid (C20: 4 n-6) content and percentage composition was significantly lower than the normal control group, while the membrane micro viscosity is higher than that of control group, and the group with DR in membrane microviscosity was higher than that without DR group. Patients with membrane microviscosity of palmitic acid (C16: 0) and stearic acid (C18: 0)% which was significantly correlated with four arachidonic acid and six acid 22 carbon (C22: 6 n-3) was negatively correlated. Conclusion the composition of erythrocyte membrane fatty acids has important influence on the decrease of membrane fluidity in patients with NIDDM, while the latter may play an important role in the development and pathogenesis of NIDDM microvascular diseases. [Keywords] red cell membrane fatty acids membrane fluidity diabetic retinopathy Changes in fatty acid components and fluidity of erythrocyte membrane and diabetic retinopathy Yang Gangyi, Qiu Hongxin, Deng Huacong, et al. Department of Internal Medicine, First Affiliated Hospital, Chongqing University of Medical Science, Chongqing 400016 [Abstract] Objective To inve