胚胎停止发育的病因探讨（Etiology of embryonic arrest）.doc

胚胎停止发育的病因探讨（Etiology of embryonic arrest） Embryonic arrest is the development of an embryo in early pregnancy for some reason. B ultrasonic examination showed the gestational sac, inner tube bud or fetal shape, no fetal heart beat, or manifested as withered eggs [1]. Belongs to the category of clinical miscarriage or stillbirth, miscarriage or abortion expired yesterday. Pridjian (1989) proposed to abolish the abortion to stop the development of embryo. There are many reasons why the embryo stops growing, and the most common reasons for most authors in recent years are summarized as follows. 1 chromosome abnormality Chromosomal abnormalities lead to embryonic agenesis and early abortion. Chromosome abnormalities, including quantity and structural abnormalities, can be divided into aneuploidy and polyploidy in the quantity, the most common abnormal karyotype is triploid, and trisomy 16 is 1 / 3, which is often fatal. Trisomy 21 is 25 to 67%, 13 trisomy is 4 to 50%, and trisomy 18 has 6 to 33% abortion. Others have haploid (45X), tetraploid because of abnormal cleavage, resulting in embryonic agenesis. Structural abnormalities are absent, balanced translocation, inversion, overlap, etc. [2]. Liu Longyan and other 3 with peripheral blood cell culture G banding karyotype analysis in 776 cases of birth defects, stillbirth, habitual abortion were examined, the results suggest that the 25 cases of abnormal karyotype, the abnormal karyotype rate was 3.2%, of which 13 cases of balanced translocation. Sun Shuyan [4] reported that the chromosome abnormality rate was 5.22%, among which 32 cases were autosomal abnormalities, accounting for 14.6% (32/219). Note that balanced translocation is the most common chromosomal abnormality. 2 abnormal uterus Abortion due to uterine defects accounted for about 10% to 15%, and common (1) abnormalities of the Mullerian duct, including unilateral uterus, double uterus and double horns, resulting in narrow uterine cavities and limited blood su