脑忆清胶囊对老年小鼠和拟痴呆大鼠记忆功能的影响（Effect of Nao Yi Qing Capsule on memory function in aged mice and rats with dementia）.doc

脑忆清胶囊对老年小鼠和拟痴呆大鼠记忆功能的影响（Effect of Nao Yi Qing Capsule on memory function in aged mice and rats with dementia） Effect of Nao Yi Qing Capsule on memory function in aged mice and rats with dementia Update Date: 2009-11-23 Click: Huang Shifu, Liang Qiyong, Chen Qinxia, Zong Qin Abstract: the Alzheimers rats model (DMR) was prepared from aged mice and A1C13 solution to study the effects of NYQ on memory function and the mechanism of action. The results show that the microstructure of DMR (Cer) in the cerebral cortex of cholinesterase (AchE) activity than normal rats increased (P 0.01), and M- receptor Rt in aged mice Cer values than normal young mice (P[K HT5 reduced 0.01), NYQ can significantly reduce the activity of AchE in Cer (P animal experiment from 0.05 to 0.01), increased M- receptor Rt (P 0.05 ~ 0.01). The results suggest that NYQ can significantly improve the memory ability by decreasing the activity of Cer in AchE and increasing the Rt value of M- receptor in experimental animals, which can be used for the treatment of senile dementia. Keyword: @ brain clear capsule / pharmacology / memory / drug effects; cholinesterase / analysis; receptor / cholinergic / analysis; Dementia, senile / TCD therapy CLC number: R285.5; R338.64 document identifier number: A, article number: 1003-9783 (1999) 03-0153-03 Naoyiqing capsule and traditional Chinese medicine preparation developed according to the ancient Ming Dynasty changed form. It has the effect of tonifying kidney, tonifying essence, nourishing heart, calming nerves and improving brain. It is mainly used to treat middle-aged and elderly people who suffer from memory loss, insomnia, excessive dreaming, neurasthenia, and mental development of children. We investigated the effects of NYQ on the cholinergic nervous system in experimental animals using an aging mouse and a pathological model of Alzheimers disease, in order to investigate its mechanism of delaying brain aging and promoting memory. 1 materials and metho