进行性脊肌萎缩症呼吸功能不全24例临床报道（Clinical features of respiratory failure in 24 patients with progressive spinal muscular atrophy）.docVIP

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进行性脊肌萎缩症呼吸功能不全24例临床报道（Clinical features of respiratory failure in 24 patients with progressive spinal muscular atrophy）.doc

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进行性脊肌萎缩症呼吸功能不全24例临床报道（Clinical features of respiratory failure in 24 patients with progressive spinal muscular atrophy）

进行性脊肌萎缩症呼吸功能不全24例临床报道（Clinical features of respiratory failure in 24 patients with progressive spinal muscular atrophy） Clinical features of respiratory failure in 24 patients with progressive spinal muscular atrophy Update Date: 2009-04-24 click: Wu Xiangchun, Wu Xiangfeng, come on Keywords progressive spinal muscular atrophy; respiratory insufficiency; failure; death; CLC number: R 259, document identifier code: A Article number: 1007-5615 (2000) 03-0019-02 Progressive spinal muscular atrophy is a motor neuron disease, mainly selective invasion of anterior horn cells of the spinal cord and the emergence of a group of nervous system degenerative diseases, late invasion to the respiratory function of respiratory muscle caused by insufficiency, also can encroach on the cranial nerve and bulbar paralysis, breathing and swallowing difficulties, finally died failure. And respiratory insufficiency, and finally respiratory paralysis, respiratory failure and death. From March 1996 to September -1999 cases of spinal muscular atrophy, respiratory insufficiency in 24 cases, the comprehensive analysis report follows. 1 clinical information 1.1 of all 24 cases, 18 cases were male, 6 were female, male to female ratio was 3 to 1; the youngest 20 years old, the oldest was 63 years old, 20 ~ 30 years old in 2 cases, 31 to 40 years old in 6 cases, 41 to 50 years old in 4 cases, 50 to 60 years old in 7 cases, 61 ~ 63 years old 5 cases, average 49.4 years old; the onset time of the shortest 3 months, the longest 5 years, an average of 16.8 months from onset to chest tightness; the shortest time for 3 months, the longest 4.5 years. Of the 1.224 cases, 15 died, the longest course was 4.5 years, the shortest time was 5 months. Chest tightness, shortness of breath to death, the shortest time of 1 months, the longest 7 months, from illness to death, the average duration of 14.9 months. Death analysis: respiratory failure in 14 cases, asphyxia in 1 cases. 1.3 diagnostic criteria refer to th