醋氯芬酸（Vinegar acetic acid）.docVIP

醋氯芬酸（Vinegar acetic acid） Vinegar acetic acid [name of drug] Acetic acid English Name: Aceclofenac Other name: Aifen, Pui Ching speed, can Jing, Ning Jun, Levin, wind, Shu Fen, Fen billion Meinuo, Portsmouth, Finland, HeineKen dimension airtal, Airtal, Biofenac [clinical application] For the symptomatic treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis caused by pain and inflammation. * (1). [pharmacology] 1. the pharmacodynamics of this drug is a non steroidal anti-inflammatory drug (NSAIDs), (1) the effect is similar to that of diclofenac (8), but it can anti-inflammatory and analgesic. The mechanism of action is to decrease the synthesis of prostaglandins by inhibiting the activity of cyclo oxygenase. * (1). In addition, this drug can promote cartilage repair. * (8). Thepharmacokinetic according to foreign literature of 2. drugs, the drug is rapidly and completely absorbed after oral administration, 1.25-3 hours to reach the peak plasma concentration and bioavailability of nearly 100%, the plasma protein binding rate of more than 99.7%, the concentration in the synovial fluid in the blood concentration of 60%, the volume of distribution of about 30L. This drug is metabolized in the liver of 4- hydroxy vinegar baclofen diclofenac activity and minimal acid, drug about 2/3 mainly base on the hydroxylated metabolite form with the urinary excretion in the urine, the original drug accounted for only 1% of the dosage, the elimination rate is about 6L/h, the average elimination half-life of 4-4.3 hours. * (1). [matters needing attention] 1. contraindications (1) allergic to this drug and other NSAIDs. * (1) - (2) or suspected with gastric and duodenal ulcer and gastric and duodenal ulcer recurrence in patients with a history of. * (1) - (3) gastrointestinal hemorrhage or other bleeding or clotting disorders. * (1) - (4) in patients with severe heart failure. * (1) - (5) severe liver and renal insufficiency patients. * (1) - (6) late pregnancy w