高效液相色谱法测定法莫替丁的血药浓度（Determination of famotidine in serum by HPLC）.docVIP

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高效液相色谱法测定法莫替丁的血药浓度（Determination of famotidine in serum by HPLC）.doc

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高效液相色谱法测定法莫替丁的血药浓度（Determination of famotidine in serum by HPLC）

高效液相色谱法测定法莫替丁的血药浓度（Determination of famotidine in serum by HPLC） HPLC determination of famotidine serum concentration of.Txt, if the youth spent in idle time, then the memory of the years will be a desolate tragedy. Where there is much weeds, there are few crops, but where there are many empty words, there is little wisdom. Even if there are no flowers on the road, I can still enjoy the desert. Determination of famotidine in serum by HPLC Update Date: 2010-08-14 Click: Tong Rongsheng, Li Gang, Wu Zhengzhong Abstract: Objective: to establish a HPLC method for the determination of famotidine in serum. Methods: Nova_Pak C18 (3.9 * 150mm, 5 m) chromatographic column, column temperature 35 DEG C, acetonitrile ammonium acetate buffer (6: 94) was used as mobile phase; flow rate was 1.1ml/min; detection wavelength was 266nm. The plasma samples were treated by liquid-liquid extraction. Results: the blood concentration of famotidine ranged from 12.5 to 300ng/ml and had a good linear relationship with its peak area (gamma =0.9 996). The lowest detectable concentration of 8ng/ml, the average recovery rate was 102.39%, the precision is less than 5% days, the inter day precision is less than or equal to 6.59%. Conclusion: this method is sensitive, accurate and economical. It can be used for the study of pharmacokinetics and bioavailability of famotidine. Keyword: famotidine; high performance liquid chromatography; blood concentration; liquid-liquid extraction CLC number: R97 document code: B article number:(2000)Determination, of, Plasma, Level, of, Famotidine, by, HPLC TONG, Rongsheng, LI, Gang, WU, Zhengzhong (The, Peoples, Hospital, of, Sichuan, Province, Chengdu, 610071) ABSTRACT:OBJECTIVE:A method was established for the determination of Famotidine in plasma by HPLC.METHODS:Analytical column was C18 NovaPak (3.9 x 150mm, 5 m), the mobile phase consisted of acetate buffer Acetonitrileammoniun (6: 94), the flow rate was 1.1ml/min and column temperature was.