32 Cases naloxone treatment of neonatal hypoxic-ischemic encephalopathy（32例伴有纳洛酮治疗新生儿的缺血缺氧性脑病新生儿）.docVIP

32 Cases naloxone treatment of neonatal hypoxic-ischemic encephalopathy Author: Ning Baohua Zhang Xiufen Wang Xiaofang [Keywords] naloxone [Keywords] naloxone, hypoxic-ischemic encephalopathy, neonatal Neonatal hypoxic-ischemic encephalopathy (HIE is the neonatal perinatal serious disease, is one of the major cause of neonatal death and disability of children in our hospital in recent years naloxone treatment HIE, a significant effect, now The report is as follows. 1 Materials and Methods 1.1 Clinical data Our hospital in January 1998 -2002 in January admitted the HIE were 64 cases, 42 males, 22 females, 11 cases of premature children, full-term children 49 cases expired births 4 cases, 45 cases of natural childbirth, cesarean section nine cases, forceps seven cases attract production three cases, hospitalization days of age for 30 min to 6 days, mild in 26 cases, 24 cases of moderate and severe 14 cases are in line with “the 1996 Hangzhou conference neonatal hypoxic ischemic encephalopathy diagnosis is based on clinical indexing “[1]. were randomly divided into treatment group and control group, 32 cases in each. Treatment group, 22 males and 10 females, 13 cases of mild to moderate 11 degrees, severe 8 patients in the control group, 20 males and 12 females, 13 cases of mild, moderate 13 cases, 6 cases of severe between the two groups children with birth age, weight, mode of production and clinical score comparable, as shown in Table 1. Table 1 two sets of hypoxic-ischemic encephalopathy in neonates (slightly 1.2 Treatment Both groups were given oxygen, benzene barbiturates to control seizures, mannitol improve cerebral edema; and give the Cerebrolysin 5 mg / d into the intravenous infusion once every 10 ~ 14 d. Treatment group based on admission immediately after naloxone 0.1 mg / kg intravenously, then changed to 0.05 mg / (kg ?d intravenously for 4 for 6 h, once every 5 to 7 days. 1.3 Monitoring and evaluation standard dai