43 cases of oxaliplatin combined with fluorouracil tetrahydrofolate treatment of gastrointestinal malignancies（43例铂联合氟尿嘧啶tetrahydrofolate胃肠道恶性肿瘤的治疗）.docVIP

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43 cases of oxaliplatin combined with fluorouracil tetrahydrofolate treatment of gastrointestinal malignancies（43例铂联合氟尿嘧啶tetrahydrofolate胃肠道恶性肿瘤的治疗）.doc

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43 cases of oxaliplatin combined with fluorouracil tetrahydrofolate treatment of gastrointestinal malignancies（43例铂联合氟尿嘧啶tetrahydrofolate胃肠道恶性肿瘤的治疗）

43 cases of oxaliplatin combined with fluorouracil tetrahydrofolate treatment of gastrointestinal malignancies Author: Luo Liying Lu Shao-Min Liu Wen-chao [Keywords] tumors of the gastrointestinal tract Keywords: oxaliplatin; fluorouracil; gastrointestinal tumors; chemotherapy 0 Introduction Oxaliplatin (L-OHP is found in recent years, the third generation platinum compound chemical called L-diamine cyclohexane oxaliplatin is effective chemotherapy drugs to treat gastrointestinal tumors our department 2001-01 / 2002-01 oxaliplatin in combination with 5 - fluorouracil (5-Fu and tetrahydrofolate treatment of 43 cases of gastrointestinal tumors, and achieved good effect. 1 objects and methods 1.1 object by histopathology and cytology confirmed in patients with gastrointestinal malignancies 43 cases before chemotherapy, blood and liver and kidney function is normal clinically observable testing (X-ray, B ultrasound or CT to evaluate short-term effect. Were male 27 cases, 16 females, aged 38 to 73 (average age of 55 in group A (imported Eloxatin +5- Fu + tetrahydrofolate 17 cases, III of the seven cases, IV of 10 cases; group B (domestic Austrian platinum + 5-Fu + tetrahydrofolate) 13 cases of 26 cases, III, IV of 13 cases. Karnofsky score greater than 70%, greater than the expected lifetime of the 3mo. 1.2 oxaliplatin 125mg m-2, the vd, d1, (can only be added 50g L-1 glucose injection, infusion process should be dark, tetrahydrofolate 100 to 200mg vd continuous 5d ,5-Fu700mg m -2, vd, continuous 5d. 30min iv antiemetics before chemotherapy Leise Long 3mg, the daily amount of liquid during chemotherapy 1500 to 2000mL chemotherapy, weekly the laboratory routine blood 1-2 times, if the WBC lt;2.0 ?109 L-1 , the injection of G-CSF, if PLT lt;70 ?109 L -1, Injection of GM-CSF, 3wk cycle, at least 2 cycles or more. Efficacy according to WHO unified evaluation criteria: complete remission (CR, partial remission (PR, no change (NC, the disease progress