复发缓解型EAE大鼠长期、自然病程的病理改变和硫辛酸对视神经、轴索损伤的保护作用.pdf

目 录 中文摘要……………………………………………………………………1 英文摘要……………………………………………………………………5 研究论文复发缓解型EAE大鼠长期、自然病程的病理改变 及硫辛酸对视神经、轴索损伤的保护作用 引言········一”·“””“””．．”一“”””一”””””“”””．．”“”””一““·9 第一部分 Q一硫辛酸对复发缓解型EAE大鼠长期、自然病程中 视神经损伤的保护作用 前言···················································“············”””·”””10 日lJ吾”””“一“””“”””“””“”””“”””””””““””””“一“”””．IU 材料与方法……………………………………………………………10 结果·······································”···“一··········一·”·““一”一一“14 附l羽··-··············································“·······一····““·”·”““16 附表……………………………………………………………………24 讨论·······································”···．．”····一····”～·····…··“一“25 小结········································································““··28 参考文献………………………………………………………………28 第二部分 复发缓解型EAE大鼠长期、自然病程的病理改变 及硫辛酸对轴索损伤的作用 前言····································……………············…······……31 刚吾””””一””一”“一”““”””””””““”“””“”””一““一“”””3l 材料与方法……………………………………………………………32 结果····································……………························…36 附图··············································································39 附表··············································································50 讨论··············································································52 小结··············································································56 参考文献………………………………………………………………56 结论····················································································60 综述 多发性硬化中的视神经损伤以及长期病程中的轴索损伤………6l 致谢····················································································74 个人简历……………………………………………………………………75 一————————————————————————————————————一 中文摘要 复发缓解型EAE大鼠长期、自然病程的病理改变 及硫辛酸对视神经、轴索损伤的保护作用 摘 要 目的：本研究拟采用小剂量豚鼠全脊髓匀浆复合