about autologous peripheral blood stem cell transplantation in the treatment of diabetic lower extremity ischemic disorder efficacy（对自体外周血干细胞移植治疗糖尿病下肢缺血性疾病的功效）.docVIP

About autologous peripheral blood stem cell transplantation in the treatment of diabetic lower extremity ischemic disorder Efficacy [Abstract] Objective To observe the clinical efficacy of autologous peripheral blood stem cell (PBSC transplantation for the treatment of diabetic lower extremity ischemic vascular disease. Methods voluntarily accepted two cases autologous PBSC transplant patients with ischemic vascular disease of the lower extremities of diabetes were treated with recombinant human granulocyte colony-stimulating collected peripheral blood stem cell factor 250 ~ 600μg / d, subcutaneously, line PBSC mobilization 6d. stem cell suspension affected limb transplant surgery, regular observation after assessing various indicators. 2 patients pain relief, infection was control ulcers or toe gangrene significant improvement. transplantation site angiography showed both rich capillaries Conclusion autologous PBSC transplantation for the treatment of diabetic lower extremity ischemic vascular disease is a safe and effective means. [] PBSC transplant diabetic lower extremity ischemic disorder Diabetic ischemic vascular disease many involving the lower limbs, is one of the major complications of diabetes, severe cases can lead to ulcers, gangrene, amputation hazard. Peripheral blood stem cells (peripheral blood stem cell, PBSC has a high degree of differentiation potential to differentiate into vascular endothelial cells, help neovascularization people to take advantage of this principle, autologous PBSC transplantation into the ischemic lower extremity muscles or blood vessels, it gradually differentiated vascular regeneration, improve and restore lower limb blood flow. observe the application of autologous PBSC transplantation for treatment of two cases of diabetic lower extremity ischemic vascular disease patients, a significant effect. 1 Materials and methods 1.1 Devices and Equipment One-time consumption of the MCS + ED blood cell separator