乙型肝炎肝硬化并发原发性肝癌危险因素研究.doc

乙型肝炎肝硬化并发原发性肝癌危险因素研究[摘要] 目的 探讨与分析乙型肝炎肝硬化并发原发性肝癌的危险因素。 方法 选取2007年6月～2009年6月来我院就诊的196例乙型肝炎肝硬化患者为研究对象，对其随访3年，并对其临床资料进行分析，探讨乙型肝炎肝硬化并发原发性肝癌的危险因素。结果 性别、长期吸烟史、肝癌家族史、其他肿瘤家族史、糖尿病、抗病毒治疗及HBV DNA水平均会影响乙型肝炎肝硬化并发原发性肝癌的发生。而长期吸烟史、糖尿病、未予以抗病毒治疗及HBV DNA阳性为乙型肝炎肝硬化并发原发性肝癌的独立危险因素。结论 对长期吸烟史、伴有糖尿病、未予以抗病毒治疗及HBV DNA阳性的乙型肝炎肝硬化患者，临床上需予以注意与预防，防止原发性肝癌（HCC）的发生。 [关键词] 乙型肝炎肝硬化；原发性肝癌；危险因素 [中图分类号] R735.7 [文献标识码] B [文章编号] 1673-9701（2013）07-0054-02 Analysis of risk factors for hepatitis B liver cirrhosis complicated with primary liver cancer YANG Xiaomin1 ZHANG Wei2 ZHEGN Hongbin3 1.Department of Gastroenterology， Taizhou Hospital of Zhejiang Province， Linhai 317000， China； 2.ICU， Taizhou Hospital of Zhejiang Province， Linhai 317000， China； 3.Department of Gastroenterology， Zhejiang Chinese Medicine University， Hangzhou 310053， China [Abstract] Objective To investigate and Analysis on risk factors of hepatitis B liver cirrhosis complicated with primary liver cancer. Methods A total of 196 cases of patients with hepatitis B liver cirrhosis from 2007 June to 2009 June in our hospital as the research object， on the follow-up of 3 years， and analysis of clinical data， investigated the risk factors of hepatitis B liver cirrhosis complicated with primary liver cancer. Results Sex， smoking history， family history of liver cancer， other cancers， diabetes， family history of antiviral therapy and HBV DNA level will impact of hepatitis B liver cirrhosis with hepatocellular carcinoma. The long history of smoking， diabetes， not to antiviral therapy and HBV DNA was independent risk of hepatitis B liver cirrhosis with hepatocellular carcinoma factors. Conclusion The long history of smoking， diabetes， not to antiviral therapy and HBV DNA positive hepatitis B liver cirrhosis， clinical need attention and prevention， prevent the occurrence of HCC. [Key words] Hepatitis B liver cirrhosis； Hepatocellular carcinoma； Risk factors 原发性肝癌（hepatocellular carcinoma，HCC）是我国病死率及流行率较高的肿瘤之一[1]。 在我国肝炎肝硬化（liver